Validation and parameter optimization of a hybrid embedded/homogenized solid tumor perfusion model

The goal of this paper is to investigate the validity a hybrid embedded/homogenized in-silico approach for modeling perfusion through solid tumors. rationale behind novel idea that only larger blood vessels have be explicitly resolved while smaller scales vasculature are homogenized. As opposed typical discrete or fully-resolved 1D-3D models, required data can obtained with in-vivo imaging techniques since morphology not necessary. By contrast, vessels, whose topology and structure attainable non-invasively, embedded as one-dimensional inclusions into three-dimensional tissue domain which modeled porous medium. A sound mortar-type formulation employed couple two representations vasculature. We validate model optimize its parameters by comparing results corresponding based on several well-defined metrics. These tests performed complex set three different tumor types heterogeneous vascular architectures. correspondence in terms mean representative elementary volume interstitial fluid pressures excellent relative errors less than 4%. Larger, but important explicable present flow smaller, homogenized vessels. finally discuss demonstrate how further improved apply it studies efficacy drug delivery.